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vanderbilt.edu
Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure.
Transmissible spongiform encephalopathies (TSEs) represent a group of fatal neurodegenerative diseases that are associated with conformational conversion of the normally monomeric and alpha-helical prion protein, PrP(C), to the beta-sheet-rich PrP(Sc). This latter conformer is believed to constitute the main component of the infectious TSE ...
Jul 23, 2020
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