In part of my discussion with Dr. Calder, he talked about how high linoleic acid intake can inhibit the endogenous conversion of the ω-3 fat ALA into EPA.A new RCT in healthy adults adds to the evidence for this. Relatively high linoleic acid intake (10% energy) leads to a reduction in EPA (ω-3) *without* affecting arachidonic acid, a major ω-6 PUFA downstream of linoleic acid.Image 1:Basic findings from the abstract.Image 2:ALA exposure (ω-3) was similar in both arms of the study (low and high
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