Lipid Nanoparticles: Formulation, Production Methods and ...
Mar 12, 2025 · Lipid nanoparticles (LNs) have emerged as advanced lipid-based delivery systems, offering an effective approach for encapsulating and protecting lipid-soluble bioactive …
Synthesis and Potential Applications of Lipid Nanoparticles in …
So far, submicrometer emulsions, liposomes, as well as microspheres, and nanospheres made of biodegradable polymers have been used in medicine. Recent studies show particular interest …
Lipid nanoparticles: Composition, formulation, and application
Jun 12, 2025 · In this review, we first introduce the LNP components, highlighting their critical roles in encapsulation, stability, delivery efficiency, and tissue tropism. Next, we summarize …
Introduction to lipid nanoparticle manufacturing and LNP synthesis …
Dec 18, 2025 · Comprehensive overview of the various synthesis methods for drug-loaded liposomes and Lipid nanoparticle / RNA-LNP manufacturing process.
Overview of LNP Synthesis, Formulation and Manufacturing …
While several traditional manufacturing methods have laid the foundation for current LNP technologies, modern methods use microfluidics for superior precision, reproducibility, and …
Microfluidic synthesis of lipid-based nanoparticles for drug …
Jan 2, 2024 · Microfluidic technologies are revolutionizing the synthesis of nanoscale lipid particles and enabling new opportunities for the production of lipid-based nanomedicines.
A complete guide to understanding Lipid nanoparticles (LNP)
Dec 23, 2025 · It examines LNP composition —ionizable lipids, phospholipids, cholesterol, and PEG—detailing how each influences stability, encapsulation efficiency, and biodistribution. …
Lipid-based nanoparticle - Wikipedia
Lipid-based nanoparticles are very small spherical particles composed of lipids. They are a novel pharmaceutical drug delivery system (part of nanoparticle drug delivery), and a novel …
Lipid nanoparticles: Composition, formulation, and application
In this review, we first introduce the LNP components, highlighting their critical roles in encapsulation, stability, delivery efficiency, and tissue tropism. Next, we summarize different …
Review on the Scale-Up Methods for the Preparation of Solid Lipid ...
Solid lipid nanoparticles (SLNs) are an alternate carrier system to liposomes, polymeric nanoparticles, and inorganic carriers. SLNs have attracted increasing attention in recent years …
Scalable synthesis of lipid nanoparticles for nucleic acid drug ...
Aug 14, 2023 · In this work, we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three dimensions.
Technological strategies for the preparation of lipid nanoparticles ...
Amid the vast diversity of nanostructured drug delivery carriers, lipid nanoparticles (LNs) stand out with their undeniable advantages like exceptive biocompatibility and multiplicity, and their …
Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview …
Aug 21, 2023 · In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and …
Lipid Nanoparticles for Advanced Drug Delivery - Nanoparticles …
Drug Delivery Systems and Lipid Nanoparticles Overview Lipid Nanoparticles as a Suitable Drug Delivery Platform Lipid nanoparticles (LNPs) are delivery vectors of nanoscale size, ranging …
Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview …
In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid …
In this review, we first in-troduce the LNP components, highlighting their critical roles in encapsulation, stability, delivery eficiency, and tissue tropism. Next, we summarize different …
Lipid nanoparticles: Different preparation techniques, …
Dec 1, 2017 · Among these, lipid-based nanoparticles have the advantage of being the least toxic for in vivo applications, and dynamic progress has been made in the area of DNA/RNA and …
Multiplexed lipid nanoparticle barcoding reveals tissue ... - Nature
6 days ago · Barcoding aids in the optimization of lipid nanoparticles. Here, the authors report on multiplexed mRNA barcoding that enables high-resolution spatiotemporal profiling of lipid …
Optimization of the Conditions of Solid Lipid Nanoparticles (SLN) Synthesis
Lipid nanoparticles were first synthesized in the early 1990s, and their synthesis was groundbreaking in the search for a new generation of nanocarriers.
Standardizing a Protocol for Streamlined Synthesis and ... - PubMed
Jul 31, 2025 · As interest in LNP-based therapies expands, there is an urgent need for low-cost, reproducible synthesis protocols that can be readily implemented across a wide range of …
Microfluidic synthesis of lipid-based nanoparticles for drug …
Sep 28, 2023 · Microfluidic technologies are revolutionizing the synthesis of nanoscale lipid particles and enabling new opportunities for the production of lipid-based nanomedicines.
Programmable Lipid Nanoparticles for RNA Therapeutics: Design ...
6 days ago · Abstract RNA therapeutics have come of age as clinically validated modalities including mRNA, siRNA, antisense oligonucleotides (ASOs), and in vivo genome editing, with …
Advanced Microfluidic Technologies for Lipid Nano-Microsystems …
From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nanoparticles, core-shell …