CYP2D6 - Wikipedia
Inhibitors of CYP2D6 can be classified by their potency, such as: Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values of sensitive substrates …
What Are CYP2D6 Inhibitors and Why Do They Matter?
Nov 26, 2025 · Cytochrome P450 2D6 (CYP2D6) is particularly important, processing an estimated 20 to 25 percent of all clinical medications. A CYP2D6 inhibitor is a substance, often …
A Scoping Review of the Evidence Behind CYP2D6 Inhibitor ...
The FDA lists 22 medications as clinical inhibitors of CYP2D6, with classifications of strong, moderate, and weak. It is accepted that strong inhibitors result in nearly null enzymatic activity, …
Cytochrome P-450 CYP2D6 Inhibitors (strong) | DrugBank
A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. A …
CYP2D6 Inhibitors: Working, Common Drugs, & More - RPh Labs
CYP2D6 inhibitors are substances that decrease the metabolic activity of the CYP2D6 enzyme, leading to altered plasma concentrations of drugs metabolized by this pathway.
What Are CYP2D6 Inhibitors and How Do They Affect You?
Jul 26, 2025 · An “inhibitor” in the context of CYP2D6 is a substance that reduces or blocks the activity of this enzyme. This interference can prevent the normal breakdown of certain …
List of Drugs That Inhibit CYP2D6 - Med Ed 101
Nov 30, 2022 · In this article I highlight my list of drugs that inhibit CYP2D6 and also share some case examples from my clinical pharmacy practice.
What Medications Inhibit CYP2D6? A Guide for Patients and …
Oct 21, 2025 · Learn which medications inhibit CYP2D6, the cytochrome P450 enzyme responsible for metabolizing a quarter of all prescription drugs, and why this can impact drug …
What drugs inhibit CYP2D6 (cytochrome P450 2D6)?
Oct 27, 2025 · Paroxetine, fluoxetine, bupropion, and quinidine are the most potent inhibitors of CYP2D6, while drugs like sertraline, citalopram, venlafaxine, and escitalo...
Table of Substrates, Inhibitors and Inducers
Index inhibitors listed in this table were selected based on potency and selectivity of inhibition, safety profiles, and an adequate number of reported clinical DDI studies with different in vivo...