Background Systemic lupus erythematosus (SLE) predominantly affects women of childbearing age and is often associated with ...

It is postulated that fibromyalgia reflects a neurobiologically rooted imbalance between overactivated threat systems and ...

Objectives The intrauterine environment may influence childhood immune-mediated disease risk. We investigated whether ...

Background Approximately 10%–20% of patients with Kawasaki disease (KD) are resistant to intravenous immunoglobulins (IVIG) ...

Objectives Eosinophilic granulomatosis with polyangiitis (EGPA) is classified as a subtype of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). A recent genome-wide association ...

Sjögren’s disease (SjD) is a chronic, multisystem autoimmune disorder characterised by lymphocytic infiltration of exocrine glands, leading to dryness, fatigue and variable extraglandular involvement.

Objectives Current therapeutic paradigms for treatment-refractory rheumatic diseases rely on chronic immunosuppression with variable efficacy and potential for cumulative toxicity. We systematically ...

Background The diagnosis of antiphospholipid syndrome (APS) uses standard antibodies (lupus anticoagulant (LAC), anticardiolipin antibodies (aCL) IgG/IgM, β2-glycoprotein I antibodies (β2GPI) IgG/IgM) ...

Objectives To explore the prevalence and distribution of ultrasound-detected inflammation and structural damage in the joints, tendons and entheses of patients who developed new-onset arthritis or ...

Objectives This 1-year long-term extension (LTE) study (NCT04451772) followed the 48-week phase 2 SLEek study (NCT03978520) that evaluated upadacitinib (a Janus kinase inhibitor) alone or combined ...

Objective Sjögren’s disease (SjD) is a chronic exocrine disorder typified by inflammation and dryness, but also profound fatigue, suggesting a pathological basis in cellular bioenergetics. In healthy ...