eLife

Defining the Antigenic Topology and Prospective Binding Breadth of Vaccination-induced SARS-CoV-2 Neutralizing Antibodies

This manuscript provides valuable high-resolution structural insights into the interaction between vaccine-elicited antibodies and SARS‑CoV‑2 evolution. The evidence is solid; however, the conclusions ...
eLife

Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

These findings are important because they suggest that more selective JAK inhibition, particularly targeting JAK1 or JAK2, can effectively reduce organ pathology and pathogenic IFN-γ-producing immune ...

Unmasking autism spectrum disorder through its gene-based roots

Two studies led by the Chahrour Lab at UT Southwestern Medical Center shed new light on genes associated with autism spectrum ...