Comparison with a concurrent cohort of 47 patients with clinically diagnosed wild-type ATTR-CM revealed a striking difference in disease burden. Systematic age- and biopsy-guided screening during ...

The relative left ventricular wall thickness, indicating relative wall thickening, was significantly higher in patients who were technetium-99m pyrophosphate (99mTc-PYP) positive compared with ...

In all, 218 proteins showed a significant association with a cardiac index. Four correlated with both LVEF and Ecc, and 42 with both LVEF and LGE. None correlated with all 3 indices. Researchers ...

Longitudinal worsening of breathlessness showed the strongest correlation with increasing anxiety and depression scores, while changes in forced vital capacity percent predicted showed no correlation.

Several genes previously associated with loss of ambulation showed no evidence of interaction with corticosteroid exposure. Genetic modifiers, particularly those in the transforming growth factor β ...

First-trimester anomaly scans promote the detection of fetal anomalies, but some cases may require an extended period of diagnostic evaluation. Introduction of a first-trimester anomaly scan (FTAS) ...

Exploratory outcomes indicated further benefits, including lower rates of myasthenic crises and hospitalizations, as well as reduced need for rescue therapy. Cemdisiran, a small interfering RNA (siRNA ...

Individuals who experienced the most rapid disease progression had relatively elevated triglycerides and liver enzymes, higher BMI, and lower HDL. Researchers used the results of frequently ordered ...

Oral corticosteroids were the most common treatment used by patients with systemic autoimmune rheumatic disease-associated interstitial lung disease whose disease had progressed to PPF. A recent study ...

New information regarding neonatal physiology related to massive hemorrhage, treatment approaches, and the current data can assist in informing evidence-based recommendations regarding the management ...

The Arg185 residue of nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 12 (NLRP12) is the direct binding site for obeticholic acid, and this interaction reduces ...

Investigators are evaluating AAV-SERCA2a in the MUSIC-DMD trial, a first-in-human study that will inform future development. The US Food and Drug Administration (FDA) has granted Fast Track ...