Rural populations have a greater prevalence of cardiovascular disease (CVD) risk factors and incident CVD, and less favorable ...

BACKGROUND: Screening for atrial fibrillation (AF) on the basis of AF risk may be more effective. We aimed to develop, ...

BACKGROUND: Metabolic adaptation and maladaptation are hallmarks of the failing heart and may be a target for therapeutic ...

Caffeine is one of the most commonly consumed drugs in the world. It is found in various naturally occurring substances and can be ingested in a synthetically derived pure form. The majority of human ...

The initial use of placebo medications in the late 18th century was not in the context of clinical trials. Placebos—or remedies given without curative intent—were often used by physicians aiming to ...

On page e955 and in Tables 18 and 19 on page e957, the subsequent references after new Reference 18 are renumbered as References 19 through 37. On page e1029, in “Appendix 2. Reviewer Relationships ...

Downregulation of ECHS1 was observed in human hearts with hypertrophic cardiomyopathy (Figure [B]). ECHS1 downregulation was coupled with the upregulation of H3K18cr and H2BK12cr (Figure [C]), ...

This study combined the 2 newly generated Kit–Cre drivers and dual recombinase–mediated lineage tracing strategy to circumvent the Kit–Cre lineage tracing issues 3 and then address their fates in the ...

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 nuclease (Cas9)-based transcriptional repressors (CRISPRi) have emerged as powerful tools for functional ...

VESALIUS-CV is a large (N=12 257), rigorously conducted, international, randomized, placebo-controlled trial conducted in patients at high cardiovascular risk but without prior myocardial infarction ...

E‐cigarettes are popular for smoking cessation and as an alternative to combustible cigarettes. We assess the association between e‐cigarette use and having had a myocardial infarction (MI) and ...

Older randomized trials have shown modest benefit for carotid endarterectomy for selected patients with asymptomatic carotid stenosis compared with medical treatment. However, improvements in ...