Lupus Science & Medicine

Inflammation in areas of fibrosis precedes loss of kidney function in lupus nephritis

Background Interstitial fibrosis in lupus nephritis (LN) is often infiltrated by immune cells but typically regarded as ...
Lupus Science & Medicine

Prevalence and predictive factors associated with sustained remission in SLE: a systematic review

Objective The question of sustained remission in SLE has been highlighted recently following data published on the use of chimeric antigen receptor-T cell therapy in SLE. With the review, we wanted to ...
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Autoimmune encephalitis associated with anti-LGI1 antibody: a potential cause of neuropsychiatric systemic lupus erythematosus

Objective To investigate the clinical features and treatment outcomes of anti-leucine-rich glioma-inactivated 1 (anti-LGI1) encephalitis in patients with SLE. Methods Between October 2014 and April ...
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Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and ...

Objectives Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Significant morbidity and early mortality necessitate early intervention. This study harnessed SLE-associated immune ...
lupus.bmj

PS7:129 Synergetic b-cell immunomodulation with rituximab and belimumab combination treatment in severe, refractory sle

Background Neutrophil extracellular traps (NETs) are auto-antigenic DNA strands and potentially give rise to SLE-specific autoantibodies that can deposit in glomeruli. It has been shown that ...
lupus.bmj

17 Type I interferon modulates ADAM17 activity in photosensitive lupus mouse models

Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by systemic disease flares, renal complications, photosensitivity, and other clinical manifestations. A research ...
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Clinical and histological findings at second but not at first kidney biopsy predict end-stage kidney disease in a large multicentric cohort of patients with active lupus nephritis

Objective To investigate second kidney biopsy as predictor of end-stage kidney disease (ESKD) in active lupus nephritis (LN). Methods Patients with biopsy-proven LN (International Society of ...
Lupus Science & Medicine

Development and validation of nomograms for predicting activity index and tubulointerstitial lesions in lupus nephritis: a multicentre study

Objective Lupus nephritis (LN) is a prevalent renal manifestation in patients with SLE, with kidney biopsy remaining the gold ...
lupus.bmj

28 JAK-STAT inhibitors in systemic lupus erythematosus

Janus kinase (JAK) inhibitors have enriched our armamentarium to treat autoimmune rheumatic diseases, with their approval in inflammatory arthritides (rheumatoid arthritis, spondyloarthritides). The ...
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LP-184 Rationale and design of two phase 3, Randomized, double-blind, placebo-controlled studies of the efficacy and safety of litifilimab in adults with active systemic lupus ...

Background Litifilimab is a humanized IgG1 monoclonal antibody targeting BDCA2, a receptor predominantly expressed on plasmacytoid dendritic cells (pDCs). In Part A of the Phase 2 LILAC study ...
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LBP5 Real-life data of anifrolumab as a treatment for systemic lupus erythematosus (SLE)

Objective To analyze the efficacy of Anifrolumab with SLE in patients from a real-life cohort. Methods A single-center observational study was performed including patients with a diagnosis of SLE who ...