The researchers identified 158 mtDNA variants across samples, with a higher variant burden in stillbirth cases without cardiac conduction system abnormalities. Mitochondrial DNA (mtDNA) alterations ...

There is a dichotomy in quality-of-life outcomes in patients with PAH, with significant physical impairments and relatively preserved mental health scores. Patient-reported outcome measures play a key ...

All-cause mortality in placebo groups at 12 months decreased from 9% in the ATTR-ACT trial to 4.3% in HELIOS-B. Patients enrolled in more recent clinical trials for transthyretin-mediated amyloid ...

The relative left ventricular wall thickness, indicating relative wall thickening, was significantly higher in patients who were technetium-99m pyrophosphate (99mTc-PYP) positive compared with ...

In all, 218 proteins showed a significant association with a cardiac index. Four correlated with both LVEF and Ecc, and 42 with both LVEF and LGE. None correlated with all 3 indices. Researchers ...

The risk of occurrence of the clinical trial's endpoints was lower in patients with PPF treated with 9 mg or 18 mg twice a day compared with those given the placebo. Treatment with nerandomilast at a ...

Rare Disease Advisor, a trusted source of medical news and feature content for healthcare providers, offers clinicians insight into the latest research to inform clinical practice and improve patient ...

Individuals with advanced liver disease may also experience significant weight loss due to nausea and poor appetite. Candidates for liver transplantation may need to gain weight to optimize surgical ...

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare acquired autoimmune neurological disorder in which both T-cell-mediated and humoral immune mechanisms target healthy myelinated ...

The high-output heart failure cohort was characterized by an increased frequency of secondary MF and lower baseline hemoglobin levels. Echocardiographic high-output heart failure in patients with ...

Test Your Knowledge About the Genetics of Chronic Lymphocytic Leukemia Test Your Knowledge About the Prognosis of Chronic Lymphocytic Leukemia Test Your Knowledge About the Diagnosis of Chronic ...

A new phase 2 clinical trial to test the safety, efficacy, and tolerability of TAK-411 for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP) is now open. The open-label, ...