Identifying what separates a best-in-class ADC from an adequate one is complicated by the fact that no single technique or innovation determines s ...

Effective 483 remediation requires funded cross-functional investigations, senior leadership accountability, and routine ...

Optimizing sample preparation is critical for generating high-quality, reproducible analytical data, particularly when working with complex matrices. Yet, it often demands significant time and effort.

Applying Py-GC–MS supports polymer-specific quantification of microplastics in playground matrices, strengthening exposure-risk estimation and environmental health monitoring. Characterizing Greek ...

Artificial-saliva extraction demonstrated ubiquitous salivary mobilization of PFAS from stuffed toys, highlighting mouthing as a plausible early-life exposure pathway often omitted from product risk ...

HILIC outperforms C18 for CCM intermediates because hydrophilic and weak electrostatic interactions retain polar analytes while preserving compatibility with shared MS platforms. Peak tailing, ...

Three parallel scientific tracks cover chromatographic fundamentals, omics-driven bioanalysis, and hyphenation technologies, emphasizing global invited expertise in separation science and MS-coupled ...

Summary: A preview of 2026 separation science trends, from PFAS and SFC to metabolomics, next-generation HPLC columns, oligonucleotides, and ADC analysis. LCGC International's editorial mission is to ...

This week, LCGC International published a variety of articles on hot topics in separation science. From an interview about the latest advancements in supercritical fluid chromatography (SFC), a news ...

The quantification of the enantiomers of racemic substances is of great importance in the development and regulation of pharmaceutical compounds. Active ingredients are often chiral; typically, only ...

In the process of a liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay development for two antimicrobial drugs using their stable isotope-labeled (SIL) analogues as internal standards to ...

Partition coefficients, log P or K ow, are often used in introducing and describing new extraction techniques. They can also be used in developing new separation methods. An understanding of partition ...