BMJ

FRI0016 R835, A NOVEL IRAK1/4 DUAL INHIBITOR IN CLINICAL DEVELOPMENT, BLOCKS TOLL-LIKE RECEPTOR 4 (TLR4) SIGNALING IN HUMAN AND MOUSE

Background: Toll-Like Receptors (TLR) and Interleukin-1 Receptors (IL-1R) play a critical role in the innate immune response as microbial sensors, providing a bridge between the innate and adaptive ...
BMJ

The global burden of occupationally related low back pain: estimates from the Global Burden of Disease 2010 study

1 Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia 2 School of Public Health and Community Medicine, University of New South Wales, Sydney, New South Wales, ...
BMJ

Studies with pain rating scales.

Good correlation has been shown between pain scores derived from 4 different rating scales. The correlation was maintained when presentation of the scales was separated by a series of questions and by ...
BMJ

Raised erythrocyte sedimentation rate signals heart failure in patients with rheumatoid arthritis

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA Correspondence to: Dr Sherine E Gabriel Department of Health Sciences Research, Mayo Clinic, 200 1st St SW, Rochester, MN ...
BMJ

Nottingham knee osteoarthritis risk prediction models

Objectives (1) To develop risk prediction models for knee osteoarthritis (OA) and (2) to estimate the risk reduction that results from modification of potential risk factors. Method This was a 12-year ...
BMJ

Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000–2012

9 Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan 10 School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, ...
BMJ

Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile ...

Objectives Interferon-γ (IFNγ) is the pivotal mediator in murine models of primary haemophagocytic lymphohistiocytosis (pHLH). Given the similarities between primary and secondary HLH (sec-HLH), ...
BMJ

Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study

Objectives: To examine the size and direction of osteophyte in knee osteoarthritis (OA) and to determine associations between osteophyte size and other radiographic features. Methods: Knee radiographs ...
BMJ

The 10-year follow-up data of the Euro-Lupus Nephritis Trial comparing low-dose and high-dose intravenous cyclophosphamide

Pathology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium Correspondence to Professor F A Houssiau, Rheumatology Department, Cliniques ...
BMJ

European Scleroderma Study Group to define disease activity criteria for systemic sclerosis. III. Assessment of the construct validity of the preliminary activity criteria

Objective: To further assess the construct validity of the three European Scleroderma Study Group (EScSG) preliminary activity indices for systemic sclerosis (SSc): for SSc as a whole, for diffuse SSc ...
BMJ

Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles

1 Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands 2 Departments of Rheumatology and Epidemiology, Leiden University Medical Centre 3 Department of Immunohaematology ...
BMJ

All-cause, cause-specific and age-specific standardised mortality ratios of patients with systemic lupus erythematosus in Ontario, Canada over 43 years (1971–2013)

Correspondence to Dr Murray Urowitz, Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Lupus Clinic, Toronto, ON M5T2S8, Canada; ...