El-Sayed’s victory is a bitter defeat for establishment Democrats. Stevens was endorsed by Michigan governor Gretchen Whitmer, had the backing of the state’s traditionally powerful black community, and benefited from millions of dollars poured into the race by outside groups.

The FDA has approved the U.S.’s first mRNA flu shot. Such mRNA vaccines can be manufactured much faster than traditional ones, allowing scientists to better match circulating influenza strains. In a late-stage trial, mFlusiva — from drugmaker Moderna — was found to be about 27% more effective than a standard flu shot.