Analytical ultracentrifugation is an established method during the development of therapeutic proteins and antibodies and contributes supporting information regarding the size, oligomerization state ...

AAVs and LNPs are complementary gene transfer systems with respect to immunogenicity, tissue tropism and types of nucleic acids, which can be delivered. AUC provides a wealth of orthogonal assays for ...

Scientists looked at multiple techniques used to measure the modified viruses deployed in some gene therapy research and treatments. One technique, known as SEC-MALS, was the most precise and accurate ...

Gene Therapy Analytics and Manufacturing, a recent conference organized by the Cambridge Healthtech Institute and held in San Diego, described itself as a way to take “an in-depth look at the ...

You have full access to this article via your institution. Unique to FDS-SV is the strongly size-dependent resolution of all species in solution, which allows not only the resolution of degradation or ...

Current and newer biologic modalities pose increasingly complex challenges to the detection and characterization of protein aggregates. Protein aggregation is a particular challenge for biologic drug ...

In a finding with implications for one of the most promising cutting-edge medical treatments, researchers evaluated several measurement techniques commonly used in gene therapy. The study determined ...

Some gene therapy treatments use modified adeno-associated viruses (AAVs) like the one shown here to deliver therapeutic genetic material into a patient’s cells. In a finding with implications for one ...