Captured mid-reaction, RNA polymerase reveals universal blueprint for gene transcription

The enzyme RNA polymerase (RNAP) carries out transcription, copying DNA into RNA. It's the first step in gene expression, and a process fundamental to all life. But the inner workings of this ...
UC San Diego Today

Water Molecules Found to Actively Drive Gene Transcription Process

Water molecules play an active, essential role in gene transcription, helping RNA polymerase II carry out the chemical steps ...
eLife

mRNA Imprinting: transcription apparatus can remotely control cytoplasmic post-transcriptional mechanisms by dozens of proteins

In this valuable study, the authors develop new approaches to investigate mRNA imprinting, a phenomenon in which RNA-protein complexes form in the nucleus to influence the fate of transcripts in the ...
The Scientist

Water Molecules Play a Vital Role in Gene Transcription

EM, researchers showed that water mediates catalysis and important protein interactions for RNA polymerase II function in ...
Frontiers

Post-Transcriptional Regulation of Bone and Cartilage Homeostasis: RNA-Mediated Mechanisms in Age-Related Osteoarthritis

Osteoarthritis (OA) is the most common age-related joint disorder, affecting more than 500 million people worldwide and representing a leading cause of ...
Labroots

Odd RNA Caps Reveal a New Kind of Gene Transcription

When a gene is active, there is cellular machinery that transcribes the sequence of that gene from DNA into messenger RNA. This is a fundamental cellular process that is essential to the proper ...
Business Wire

Research from the Lab of CAMP4 Co-Founder Richard Young Shows That RNA Binding to Transcription Factors Fine-Tunes Gene Expression

CAMBRIDGE, Mass.--(BUSINESS WIRE)--CAMP4 Therapeutics, a biotechnology company harnessing the power of regulatory RNA to restore healthy gene expression, announced research published by the lab of ...
C&EN

Click chemistry–based RNA sequencing captures bursts of transcription

The latest chemistry news, including important research advances, business and policy trends, chemical safety practices, career guidance, and more. RNA transcription isn’t a fully continuous process; ...
SpaceNews

Scripps scientists develop first examples of RNA that replicates itself indefinitely

Now, a pair of Scripps Research Institute scientists has taken a significant step toward answering that question. The scientists have synthesized for the first time RNA enzymes that can replicate ...