Definition: The extracellular matrix is the non-cellular network of proteins and polysaccharides that surrounds cells, gives tissues mechanical structure, and provides biochemical and mechanical ...

Emerging evidence suggests that extracellular matrix (ECM) states can shape both senescence entry and persistence by tuning integrin signaling and mechanosensing. We propose a self-reinforcing circuit ...

Extracellular matrix homeostasis is crucial for hyaline cartilage integrity, however, the mechanism of extracellular matrix homeostasis in hyaline cartilage is poorly understood. Single-cell ...