Missing DNA replication step revealed in first image of pre-initiation complex

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
Nature

Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon

CRISPR-associated transposons (CASTs) are mobile genetic elements that co-opted CRISPR-Cas systems for RNA-guided transposition. Here we present the 2.4 Å cryo-EM structure of the Scytonema hofmannii ...

Open-source software unlocks rapid DNA structure generation and analysis in one workflow

Computational chemists at the University of Amsterdam's Van 't Hoff Institute for Molecular Sciences have developed a ...
Nature

Dynamic alternative DNA structures in biology and disease

The alternative text for this image may have been generated using AI. In this Review, we discuss the key types of non-B DNA structure with a focus on their roles in genetic instability and disease ...
Nanowerk

Thymine (T): A Key Building Block of DNA

In the double helix structure of DNA, thymine forms a base pair with adenine through two hydrogen bonds. This specific pairing is known as complementary base pairing and is essential for the stability ...
C&EN

Solving the structure of DNA

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...