Nature

Theoretical analysis of low-power optogenetic suppression of action potentials in human ventricular cardiomyocytes expressed with potassium-selective channelrhodopsins

In our simulations conditions, WiChR and HcKCR1 achieved complete and reversible suppression of ongoing electrical activity within the irradiance range explored. ChR2(H134R) and ChRmine also reduced ...
Nature

Cell-specific models of hiPSC-CMs developed by the gradient-based parameter optimization method fitting two different action potential waveforms

The human cardiac action potential (AP) is characterized by the long-lasting plateau phase of the action potential, which lasts for a few hundreds of milliseconds. The AP plateau phase is generated by ...