Clusters of proteins found on neurons are calcium-signaling “hotspots” that link electrical signals to gene expression, allowing neurons to produce crucial proteins. The discovery may potentially lead ...

Taking out the garbage is a crucial step in housecleaning. Similarly, autophagy is the body’s first-line of defense against the buildup up of toxic substances, degrading old organelles and proteins to ...

A little extra calcium is a good thing, to help maintain healthy bones and muscles. However, too much calcium in your neurons could be an underlying cause of memory loss for those afflicted with ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...

Alzheimer’s disease is known for its slow attack on neurons crucial to memory and cognition. But why are these particular neurons in aging brains so susceptible to the disease’s ravages, while others ...

Neurobiologists have found new evidence that specific calcium channel subunits play a crucial role in the development of excitatory and inhibitory synapses. The ability of the human brain to process ...

An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study published in Science Signaling led by ...

An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study. Targeting this protein -- the ORAI1 calcium ...

Myotonic dystrophy is one of the most common forms of muscular dystrophy. It is a genetic condition that causes progressive muscle weakness and wasting. No treatments currently exist that slow the ...

Praxis Precision Medicines' ulixacaltamide (PRAX-944) is a potent and selective small molecule T-type Ca2+ channel blocker being developed for the potential treatment of essential tremor. ET is a ...