Every year, more than 100 million animals are used globally in biomedical research, yet over 90% of drugs that appear effective in animal trials fail during human clinical testing. 1 This staggering ...

The FDA Modernization Act 2.0 has shifted from animal testing to New Approach Methodologies (NAMs) for preclinical drug development. Three-dimensional (3D) bioprinting has emerged as a premier NAM, ...

Researchers are increasingly using organ-on-chips and organoids alongside or instead of animals to model drug safety, biological mechanisms and rare diseases. You have full access to this article via ...

A fundamental challenge in preclinical research is accurately predicting human responses using conventional animal models. Traditional approaches often fail to adequately model human disease, creating ...

Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Nicheformer, the first large-scale foundation model that integrates single-cell analysis with spatial ...

How do biological cells join forces to form a structure? In her Ph.D. research, Daphne Nesenberend uses mathematics to show how forces and cooperation between cells create structure—and how ...

The team observed the emergence of the three-dimensional embryo-like structures under a microscope in the lab. These started producing blood (seen here in red) after around two weeks of development - ...