Pickens County’s first and only homeless shelter, that’s helped thousands for nearly a decade, may lose its home after the ...

Upstate Medical University is holding a groundbreaking ceremony for a new, state-of-the-art laboratory called the Upstate ...

Manhole inspections will be taking place in the Upstate, starting Sunday night. What's in Trump's big bill that passed ...

One person is dead following a crash in York County, South Carolina.South Carolina Highway Patrol said troopers were called ...

Two youth baseball coaches have been fired after they were filmed stripping naked and streaking at an upstate New York ...

The Pickens County Sheriff’s Office said it is holding a blood drive to help a 14-year-old diagnosed with a rare cancer.

Upstate festivals this summer have something for everyone, from music to plays to food and more. Here's when, where and how ...

The Oconee County Sheriff's Office is investigating a shooting that happened at Lake Hartwell.According to deputes, they were ...

Maryellen Sheridan, a pediatric clinical nurse specialist at Upstate Golisano Children’s Hospital, has become president of ...

Two other upstate waterways, one in Western New York and one in the Adirondacks, also made the list of the nation's best ...

There are more than a dozen victims. The couple used the money to gamble, pay bills and buy vehicles, authorities said.