The Bills’ odds haven’t taken a huge hit for Week 11, despite facing a marquee matchup against the Tampa Bay Buccaneers. The Bills are 5.5-point favorites. Tampa Bay and Buffalo have both lost a bit of shine in the last week (TB lost to the Patriots in the Tom Brady Former Teams Bowl), but could easily right the ship with a win here.

NFL scores and reports from week 10 of the NFL as the Buffalo Bills are upset by the Miami Dolphins, while the Detroit Lions, Seattle Seahawks and Los Angeles Rams dominate the late games.

Bills: A shocking upset loss to Miami dropped the Bills to 6-3, and they're facing an uphill battle to unseat the Patriots in the AFC East. The Bills fell from +600 to +1000 to win the Super Bowl after Week 10.

How do all 32 teams in the NFL stack up against each other coming out of Week 10 of the 2025 NFL regular season? Here's an updated look from best to worst.

Our pick of week 10 in the NFL includes analysis of Buffalo's shock defeat in Miami, why the Patriots have a path to a top seed and the records Jonathan Taylor could break.

Jonathan Taylor is the runaway NFL MVP favorite. Overreaction or reality: Overreaction. Jonathan Taylor has been sensational in 2025. Otherworldly even. He just tallied 244 yards

According to NFL Network, the Bills were involved in the Williams sweepstakes but did not win out. The Jets instead sent their star defensive tackle to the Cowboys for a 2026 second-round pick, a 2027 first-round pick and defensive tackle Mazi Smith.

Josh Allen threw an interception and lost a fumble as Buffalo's receivers failed to get open consistently against Miami, dropping the Bills further in the AFC East standings.