American Airlines said that the 4% reduction will mean 220 canceled flights per day. The vast majority of impacted American Airlines flights are regional, and there’ll be no impact to international flights including Mexico, Canada and the Caribbean, CEO David Seymour said in a letter to employees. Further hub-to-hub routes impact will be minimized.

FAA’s flight reductions at major airports will strain capacity for time-sensitive shipments like pharmaceuticals, electronics and perishables.

The Federal Aviation Administration is gearing up to cut 10% of flights at 40 U.S. airports beginning Friday, Nov. 7, as air traffic controllers and TSA agents continue to go unpaid during the government shutdown.

Major airlines say that most passengers whose flights are canceled, and many who choose not to fly, will be eligible for refunds and no-fee rebookings.

Transportation Secretary Sean Duffy announced 40 major airports would face a 10% cut in flights. See the full list of impacted airports.