49ers, Tennessee Titans
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Pearsall, San Francisco 49ers
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Philip Rivers will start for Colts next Mon. night vs 49ers
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49ers can clinch playoff berth in three different ways
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49ers make final decision on WR Brandon Aiyuk
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Edge rushers and safeties dominated PFF grades. Find out who shined and where the 49ers' defense still faces challenges.
Niners Wire on MSN
Brock Purdy passes 3-time All-Pro in 49ers' career passing leaders
San Francisco 49ers quarterback Brock Purdy has moved into ninth in passing yards in franchise history, surpassing Frankie Albert.
Two defensive stars were lost for the season. Their QB missed multiple games. Still, here are the 49ers are, a game out of the No. 1 seed.
Expert recap and game analysis of the San Francisco 49ers vs. Tennessee Titans NFL game from December 14, 2025 on ESPN.
NBC Sports Bay Area on MSN
Where 49ers star players stack up in final round of 2026 NFL Pro Bowl fan voting
San Francisco 49ers stars Christian McCaffrey and Kyle Juszczyk both sit atop their positions in Pro Bowl fan voting.
Meanwhile, the 49ers are set to get some much-needed reinforcements on run defense, and Ricky Pearsall's status for Week 16 is unclear.
The San Francisco 49ers' defense is lacking playmaking and game-changing threats. Nick Bosa and Fred Warner were supposed to be those players, and they even drafted Mykel Williams to have that type of role as well.
SB Nation on MSN
Breaking down the path for the 49ers to get the No. 1 seed
In that scenario, Seattle would be at 11-3 and take the No. 1 seed, while the Rams would slide to 10-4. A 49ers win over the Colts bumps them to the No. 5 seed, while the Rams would fall to No. 6 due to their divisional record (4-1 for the 49ers vs. 3-2 for the Rams).